1 edition of Toxicity of ethylene oxide and its relevance to man. found in the catalog.
Toxicity of ethylene oxide and its relevance to man.
by European Chemical Industry Ecology & Toxicology Centre in Brussels
Written in English
Bibliography: p. 63-73.
|Series||Technical report / ECETOC -- no. 5, Technical report (European Chemical Industry Ecology & Toxicology Centre) -- no. 5.|
|Contributions||European Chemical Industry Ecology & Toxicology Centre|
|LC Classifications||RA1242E72 T69 1982|
|The Physical Object|
|Pagination||ii, 75 p. :|
|Number of Pages||75|
A model of the ethylene oxide molecule. At room temperature, ethylene oxide is a flammable colorless gas with a sweet odor. It is used primarily to produce other chemicals, including antifreeze. In smaller amounts, ethylene oxide is used as a pesticide and a sterilizing agent. The ability of ethylene oxide to damage DNA makes it an effective. Ethylene oxide was first produced in the United States in Until , it was produced by the chlorohydrin process, in which ethyl-ene was treated with hypochlorous acid to produce ethylene chlo-rohydrin, and calcium hydroxide or sodium hydroxide was used to convert ethylene chlorohydrin to ethylene oxide. Essentially all Size: KB.
Ethylene glycol (EG; CAS RN ) and its related oligomers include mono-, di-, tri-, tetra-, and penta-EG. All of the EGs are quickly and extensively absorbed following ingestion and. Ethylene oxide has a molecular formula of C2H4O. It is a colorless, flammable gas at ambient temperature and pressure condensing to a liquid below 12°C. It is highly soluble in water and many organic solvents. Liquid ethylene oxide is miscible wit.
Toxicity of methanol,ethanol ethylene glycol 1. TOXICITY OF METHANOL,ETHANOL ETHYLENE GLYCOL: Shivam Patel 2. ALCOHOL Alcohol is any organic compound in which the hydroxyl functional group (–OH) is bound to a saturated carbon atom. General Formula:CnH2n+1OH. Ball and stick model of the hydroxyl (-OH) functional group in an alcohol molecule (R3COH). The three . Under the authority of the Federal Advisory Committee Act (FACA) P.L. of , the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances (NAC/AEGL Committee) has been established to identify, review and interpret relevant toxicologic and other scientific data and develop AEGLs for high-priority, acutely toxic chemicals.
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Med Lav. Jul-Aug;75(4) [Toxicity of ethylene oxide and its importance for man]. [Article in Italian] Sarto F. PMID: Cited by: 1. ON MAN. Inhalation of the vapour.
A concentration of 1: ethylene oxide was put up in a small chamber and breathed by four subjects. It had a not unpleasant acetic acid-like smell and was slightly irritant to the nasal passages, but produced no after-effects.
Breathed in a concentration of 1: 80, the compound has a definite irritating. Toxicity of ethylene oxide and its importance for man (PMID) Abstract Citations; Related Articles; Data; BioEntities; External Links ' ' Sarto F La Medicina del Lavoro [01 Jul75(4)] Type: Research Support, Non-U.S.
Gov't, Journal Article, English Cited by: 1. The systemic toxicity of the ethylene-based glycol ethers is mediated by their metabolism to the corresponding alkoxyacetic acids. Methyl- and ethyl-substituted ethylene glycol ethers can cause bone marrow depression, testicular atrophy, developmental toxicity, and immunotoxicity in animals.
In this paper some of the physical and chemical properties of ethylene oxide are described and also its preparation and its use in the synthesis of organic compounds.
It is frequently employed in industry, for example in the manufacture of certain detergents and synthetic perfumes, as a disinfectant of cereals and of dates, and as a : M. Marchand, R. Deiesvaux, C. Claeys, F.
Lejeune. ECETOC () Toxicity of ethylene oxide and its relevance to man, Technical Report No. European Chemical Industry Ecology and Toxicology Centre, Avenue LouiseBrussels. Ehrenberg, L., K.D. Hiesche, S. Osterman-Golkar and I. Wennberg () Evaluation of genetic risks of alkylating agents: tissue doses in the mouse from air contaminated with ethylene oxide, Mutation Res., 24, 83 Cited by: Ethylene Oxide.
Hazard Summary. The major use of ethylene Toxicity of ethylene oxide and its relevance to man. book is as a chemical intermediate in the manufacture of ethylene glycol. Ethylene oxide is also used as a sterilizing agent for medical equipment and a fumigating agent for spices.
The acute (short-term) effects of ethylene oxide in humans consist mainly of central nervous. The database for ethylene oxide is very large; humans and experimental animal studies on acute toxicity, developmental and reproductive toxicity, genetic toxicity (somatic and germ cells), carcinogenicity, and pharmacokinetics and metabolism were available.
These data were used to derive the AEGL values. Ethylene oxide is already known to be a very toxic chemical. It is one of the 33 most hazardous air pollutants identified by EPA as posing the greatest human health risk in.
The use of ETO evolved when few alternatives existed for sterilizing heat- and moisture-sensitive medical devices; however, favorable properties (Table 6) account for its continued widespread use.
Two ETO gas mixtures are available to replace ETO-chlorofluorocarbon (CFC) mixtures for large capacity, tank-supplied sterilizers. The ETO-carbon dioxide (CO 2) mixture consists of %. Ethylene oxide, called oxirane by IUPAC, is an organic compound with the formula C 2 H 4 is a cyclic ether and the simplest epoxide: a three-membered ring consisting of one oxygen atom and two carbon ne oxide is a colorless and flammable gas with a faintly sweet odor.
Because it is a strained ring, ethylene oxide easily participates in a number of addition reactions that Chemical formula: C₂H₄O. Introduction. Ethylene Oxide (EtO) is a colorless, flammable gas that smells like ether at toxic levels. EtO is workable gas for many industrial and commercial purposes as intermediate, fumigant and sterilant of medical equipment’s.
Summary: Ethylene oxide is a flammable gas with a somewhat sweet odor. It dissolves easily in water. It dissolves easily in water. Ethylene oxide is a man-made chemical that is used primarily to make ethylene glycol (a chemical used to make antifreeze and polyester).
PEG owes its widespread use to a combination of low toxicity  and 'stealth' character, which can be summarized as a prolonged circulation in body fluids and reduced clearance, as a result of negligible protein adsorption (opsonization) [4,7] and low activation of immune system components . Occupational exposure to ethylene oxide in women sterilising staff working in Gauteng province, South Africa: exposure assessment and association with adverse reproductive outcome.
Presented at the Annual Research Day, School of Public Health, the University. Toxicity of ethylene oxide and its relevance to man. European Chemical Industry Ecology & Toxicology Centre, Ave. LouiseBruxelles Google Scholar Ehrenberg L, Hiesche KD, Osterman-Golkar S, Wennberg I () Evaluation of genetic risks of alkylating by: Ethylene oxide is toxic and has a long-term maximum exposure limit of 5 ppm.
The odor of pure ethylene oxide is not detectable by many people below about ppm, and while impurities present in the industrial material reduce the odor threshold considerably, odor is not a reliable guide to its presence, and artificial means are necessary.
Revised IDLH: ppm [Unchanged] Basis for revised IDLH: Based on acute inhalation toxicity data in humans [Clayton and Clayton ; NRC ; Walker and Greeson ] the original IDLH for ethylene oxide ( ppm) is not being revised at this time. [Note: NIOSH recommends as part of its carcinogen policy that the "most protective" respirators be worn for ethylene oxide at.
The authors describe detailed experiments designed to investigate the chronic toxicity of ethylene oxide. The oxide was fed to laboratory animals by intubation as a 10 per cent. solution in olive oil, applied to the skin in 10 or 50 per cent. aqueous solution, and administered as the vapour in chronic inhalation experiments.
Repeated oral doses of gm. per kgm. over 30 days caused no toxic Cited by: Toxicity of ethylene oxide and its relevance to man.
European Chemical Industry Ecology & Toxicology Centre, Ave. LouiseBruxelles Google Scholar Filser JG, Bolt HM () Pharmacokinetics of halogenated ethylenes in by:. As a part of the chemical industry’s responsible management of its products, the Ethylene Oxide Panel Ethylene Oxide Safety Task Group (STG), a group comprised of producers and industrial users, developed the Ethylene Oxide Product Stewardship Manual – 3rd edition.Ethylene oxide is the smallest of the oxirane family of molecules.
It is a sweet-smelling, colorless gas that has many uses; but its high reactivity presents many hazards. Back inA. Wurtz treated ethylene chlorohydrin with potassium hydroxide to make ethylene oxide and potassium chloride.Ethylene oxide can cause a wide variety of harmful health effects in exposed persons.
In general, with higher levels of exposure to this chemical, more severe effects will occur. The major effects seen in workers exposed to ethylene oxide at low levels for several months or years are irritation of the eyes, skin, and mucous membranes and.